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Is chewing tobacco a Safer alternative
Current evidence supports the dopaminergic hypothesis as one of the pathophysiological hypotheses for negative symptoms in SCZ, which proposes that positive symptoms are the result of overactive dopaminergic neurotransmission in the limbic pathway, whereas negative symptoms are thought to be caused by low dopaminergic function in the frontal lobes and other limbic structures of the midbrain 7,43
No difference in cardiovascular benefits could be observed between e-cigarettes containing nicotine or not, which is consistent with several observations showing that it is tobacco combustion products, not nicotine, that are responsible for the negative effects of smoking
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